Known hypersensitivity to metformin hydrochloride.
Renal disease or dysfunction which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction or septicemia.
Patients undergoing radiologic studies involving intravascular administration of iodinated contrast media. Use of such products may result in acute alteration of renal function.
Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.
Acute hemodynamic compromise of hypoxic states.
Congestive heart failure.
Abnormal hepatic function.
Dehydration.
Lactation.